I mentioned earlier that it is important to determine the hours of the day that you are the most productive in order to avoid distractions from indoors and outdoors, but what about days of the week?
Working from home normally means that you are self employed, are a freelancer, work for a company completing projects by different due dates, or you are a telecommuter. In the last case you are limited, but in the others it is best to determine when the best schedule will be for you to me the most productive.
I've discovered that my rude and noisy neighbors are even worse from Friday to Sunday so on the week end I will only work during brief breaks in the noise. Even now, at 9:30 am on Tuesday I hear a strong bass beat coming through the walls (probably 2 homes down) so you just have to imagine what it is like on the weekend.
Take into consideration your own situation. If you have children living with you, they might be a huge distraction on the weekend unless they go visit grandma or their aunt. Are there certain days when you have fewer conflicts with your time? Perhaps you can take turns baby sitting with a neighbor so you both can work the other days.
Determine which days of the week are best for you set a schedule of days and hours and let those you live and work with when you'll be available for work issues and for fun.